USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P02511 USC-OGP 2-DE database:  P02511 P02511 General information about the entry View entry in simple text format Entry name CRYAB_HUMAN Primary accession number P02511 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Alpha-crystallin B chain; AltName: Full=Alpha(B)-crystallin; AltName: Full=Heat shock protein beta-5; Short=HspB5; AltName: Full=Renal carcinoma antigen NY-REN-27; AltName: Full=Rosenthal fiber component;. Gene name Name=CRYAB Synonyms=CRYA2, HSPB5 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1314: pI=7.01; Mw=20959 Cross-references UniProtKB/Swiss-Prot P02511; CRYAB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CRYAB_HUMAN Primary accession number P02511 Secondary accession number(s) B0YIX0 O43416 Q9UC37 Q9UC38 Q9UC39 Q9UC40 Q9UC41 Sequence was last modified on  January 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 202) Name and origin of the protein Description RecName: Full=Alpha-crystallin B chain; AltName: Full=Alpha(B)-crystallin; AltName: Full=Heat shock protein beta-5; Short=HspB5; AltName: Full=Renal carcinoma antigen NY-REN-27; AltName: Full=Rosenthal fiber component; Gene name Name=CRYAB Synonyms=CRYA2, HSPB5 Encoded on Name=CRYAB; Synonyms=CRYA2, HSPB5 Keywords 3D-structure; Acetylation; Cardiomyopathy; Cataract; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Eye lens protein; Glycoprotein; Metal-binding; Myofibrillar myopathy; Nucleus; Oxidation; Phosphoprotein; Polymorphism; Reference proteome; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M28638; AAA52104.1; -; Genomic_DNA EMBL S45630; AAB23453.1; -; mRNA EMBL AF007162; AAC19161.1; -; mRNA EMBL AK314029; BAG36739.1; -; mRNA EMBL BT006770; AAP35416.1; -; mRNA EMBL EF444955; ACA05949.1; -; Genomic_DNA EMBL CH471065; EAW67162.1; -; Genomic_DNA EMBL BC007008; AAH07008.1; -; mRNA EMBL M24906; AAA60267.1; -; mRNA CCDS CCDS8351.1; -; . PIR A35332; CYHUAB; . RefSeq NP_001276736.1; NM_001289807.1; . RefSeq NP_001276737.1; NM_001289808.1; . RefSeq NP_001876.1; NM_001885.2; . RefSeq XP_011540910.1; XM_011542608.1; . UniGene Hs.53454; -; . UniGene Hs.703770; -; . PDB 2KLR; NMR; -; A/B=1-175 PDB 2N0K; NMR; -; A/B=64-152 PDB 2WJ7; X-ray; 2.63 A; A/B/C/D/E=67-157 PDB 2Y1Y; X-ray; 2.00 A; A=71-157 PDB 2Y1Z; X-ray; 2.50 A; A/B=67-157 PDB 2Y22; X-ray; 3.70 A; A/B/C/D/E/F=67-157 PDB 2YGD; EM; 9.40 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-175 PDB 3J07; Other; -; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-175 PDB 3L1G; X-ray; 3.32 A; A=68-162 PDB 3SGM; X-ray; 1.70 A; A/B/C/D=90-100 PDB 3SGN; X-ray; 2.81 A; A/B=90-100 PDB 3SGO; X-ray; 2.56 A; A=90-100 PDB 3SGP; X-ray; 1.40 A; A/B/C/D=90-100 PDB 3SGR; X-ray; 2.17 A; A/B/C/D/E/F=90-100 PDB 3SGS; X-ray; 1.70 A; A=95-100 PDB 4M5S; X-ray; 1.37 A; A=68-153 B=156-164 PDB; 4M5T; X-ray; 2.00 A A/C/E/G=68-153 B/D/F/H=156-164; PDBsum; 2KLR; - PDBsum 2N0K; -; . PDBsum 2WJ7; -; . PDBsum 2Y1Y; -; . PDBsum 2Y1Z; -; . PDBsum 2Y22; -; . PDBsum 2YGD; -; . PDBsum 3J07; -; . PDBsum 3L1G; -; . PDBsum 3SGM; -; . PDBsum 3SGN; -; . PDBsum 3SGO; -; . PDBsum 3SGP; -; . PDBsum 3SGR; -; . PDBsum 3SGS; -; . PDBsum 4M5S; -; . PDBsum 4M5T; -; . DisProt DP00445; -; . ProteinModelPortal P02511; -; . SMR P02511; -; . BioGrid 107800; 110; . DIP DIP-35017N; -; . IntAct P02511; 20; . MINT MINT-221013; -; . STRING 9606.ENSP00000227251; -; . ChEMBL CHEMBL3621022; -; . iPTMnet P02511; -; . PhosphoSitePlus P02511; -; . UniCarbKB P02511; -; . BioMuta CRYAB; -; . DMDM 117385; -; . REPRODUCTION-2DPAGE IPI00021369; -; . SWISS-2DPAGE P02511; -; . UCD-2DPAGE P02511; -; . EPD P02511; -; . PaxDb P02511; -; . PeptideAtlas P02511; -; . PRIDE P02511; -; . DNASU 1410; -; . Ensembl ENST00000227251; ENSP00000227251; ENSG00000109846; . Ensembl ENST00000526180; ENSP00000436051; ENSG00000109846; . Ensembl ENST00000527950; ENSP00000437149; ENSG00000109846; . Ensembl ENST00000531198; ENSP00000434247; ENSG00000109846; . Ensembl ENST00000533475; ENSP00000433560; ENSG00000109846; . Ensembl ENST00000616970; ENSP00000483554; ENSG00000109846; . GeneID 1410; -; . KEGG hsa:1410; -; . CTD 1410; -; . DisGeNET 1410; -; . GeneCards CRYAB; -; . GeneReviews CRYAB; -; . HGNC HGNC:2389; CRYAB; . HPA CAB002053; -; . HPA CAB040560; -; . HPA HPA057100; -; . MalaCards CRYAB; -; . MIM 123590; gene; . MIM 608810; phenotype; . MIM 613763; phenotype; . MIM 613869; phenotype; . MIM 615184; phenotype; . neXtProt NX_P02511; -; . OpenTargets ENSG00000109846; -; . Orphanet 399058; Alpha-B crystallin-related late-onset distal myopathy; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 280553; Fatal infantile hypertonic myofibrillar myopathy; . Orphanet 98993; Posterior polar cataract; . Orphanet 98995; Zonular cataract; . PharmGKB PA26907; -; . eggNOG KOG3591; Eukaryota; . eggNOG ENOG410YERS; LUCA; . GeneTree ENSGT00760000119238; -; . HOVERGEN HBG054766; -; . InParanoid P02511; -; . KO K09542; -; . OMA TITAPMK; -; . OrthoDB EOG091G0USC; -; . PhylomeDB P02511; -; . TreeFam TF105049; -; . Reactome R-HSA-3371571; HSF1-dependent transactivation; . ChiTaRS CRYAB; human; . EvolutionaryTrace P02511; -; . GeneWiki CRYAB; -; . GenomeRNAi 1410; -; . PMAP-CutDB P02511; -; . PRO PR:P02511; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000109846; -; . CleanEx HS_CRYAB; -; . ExpressionAtlas P02511; baseline and differential; . Genevisible P02511; HS; . GO GO:0032432; C:actin filament bundle; IEA:Ensembl; . GO GO:0030424; C:axon; IEA:Ensembl; . GO GO:0097512; C:cardiac myofibril; IEA:Ensembl; . GO GO:0009986; C:cell surface; IEA:Ensembl; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0043197; C:dendritic spine; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; IEA:Ensembl; . GO GO:0031674; C:I band; IEA:Ensembl; . GO GO:0031430; C:M band; IEA:Ensembl; . GO GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043204; C:perikaryon; IEA:Ensembl; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0097060; C:synaptic membrane; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW; . GO GO:0051082; F:unfolded protein binding; IPI:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0071480; P:cellular response to gamma radiation; IMP:MGI; . GO GO:0031109; P:microtubule polymerization or depolymerization; IEA:Ensembl; . GO GO:0006936; P:muscle contraction; TAS:ProtInc; . GO GO:1905907; P:negative regulation of amyloid fibril formation; IDA:ARUK-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; IDA:HGNC; . GO GO:0030308; P:negative regulation of cell growth; IEA:Ensembl; . GO GO:0032387; P:negative regulation of intracellular transport; IDA:HGNC; . GO GO:0032463; P:negative regulation of protein homooligomerization; IDA:ARUK-UCL; . GO GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl; . GO GO:0006457; P:protein folding; NAS:ProtInc; . GO GO:0051260; P:protein homooligomerization; IDA:UniProtKB; . GO GO:0010941; P:regulation of cell death; IMP:MGI; . GO GO:1900034; P:regulation of cellular response to heat; TAS:Reactome; . GO GO:0032355; P:response to estradiol; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; . GO GO:0051403; P:stress-activated MAPK cascade; IEA:Ensembl; . Gene3D 2.60.40.790; -; 1; . InterPro IPR002068; A-crystallin/Hsp20_dom; . InterPro IPR001436; Alpha-crystallin/HSP; . InterPro IPR012273; Alpha-crystallin_B; . InterPro IPR003090; Alpha-crystallin_N; . InterPro IPR031107; HSP20; . InterPro IPR008978; HSP20-like_chaperone; . PANTHER PTHR11527; PTHR11527; 1; . PANTHER PTHR11527:SF229; PTHR11527:SF229; 1; . Pfam PF00525; Crystallin; 1; . Pfam PF00011; HSP20; 1; . PIRSF PIRSF036514; Sm_HSP_B1; 1; . PRINTS PR00299; ACRYSTALLIN; . SUPFAM SSF49764; SSF49764; 1; . PROSITE PS01031; HSP20; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]